Tetanus
Conditions
Interventions
A:After the diagnosis of tetanus, the Stetudata monoclonal antibody was directly used in combination with standard treatment (debridement, antibiotics,
B:For patients who did not receive referrals from lower-level hospitals, those who had received conventional passive immunization (such as HTIG or TAT)
Sponsors
Wuhan University People's Hospital
Eligibility
Sex/Gender
All
Age
19 Years to 100 Years
Inclusion criteria
Inclusion criteria: 1. Adult patients (aged 18 years or above) with confirmed tetanus infection; 2. After excluding other causes, meet at least one of the following criteria: Typical clinical manifestations (grimacing, grimacing expression, muscle rigidity/spasm) (regardless of whether there is a history of trauma); Cultures from wound specimens detect Clostridium tetani; 3. Patients consent to participate in this study and sign the informed consent form
Exclusion criteria
Exclusion criteria: 1. Combine with other severe neurological disorders (such as encephalitis, spinal cord injury); 2. This trauma has caused irreversible brain damage (GCS remains = 5 points continuously); 3. Planned to participate in other clinical trials during the study period, but assessed by the investigator as not suitable for participation; 4. Terminal illness (expected lifespan < 3 months); 5. Pregnant, lactating women or women who plan to get pregnant during the study period, and men; 6. The investigator believes that the subject has any condition that may interfere with the assessment of the study purpose; 7. Known to be allergic to the components of the monoclonal antibody; 8. Unable to obtain informed consent from the subject or their legal representative.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ablett; | — |
Secondary
| Measure | Time frame |
|---|---|
| Titer level of anti-tetanus neutralizing antibodies;Muscle strength and muscle tone;Evaluation of Autonomic Nervous System Dysfunction;Assessment of Daily Living Skills; | — |
Countries
China
Contacts
Public ContactLiwen
Wuhan University People's Hospital
Outcome results
None listed