Breast Cancer
Conditions
Interventions
Neoadjuvant chemotherapy high benefit group:None
Sponsors
Fujian Cancer Hospital
Eligibility
Sex/Gender
Female
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Female patients aged =18 years; 2. Histopathologically confirmed invasive breast cancer; 3. Hormone receptor positive (ER and/or PR =1%); HER2 negative (IHC 0–1+, or IHC 2+ with negative FISH result); 4. Clinical stage cT1–3, cN0–2, M0 (per the 8th edition of AJCC staging system); eligible for neoadjuvant chemotherapy or primary surgery; 5. Completed standard breast MRI before treatment with image quality qualified for model analysis; 6. ECOG performance status 0–1; adequate function of major organs and tolerance to the planned treatment regimen; 7. Voluntary participation with signed written informed consent.
Exclusion criteria
Exclusion criteria: 1. Prior systemic therapy for breast cancer; 2. Inflammatory breast cancer or distant metastasis (M1); 3. Concurrent active malignancies; 4. Contraindications to MRI or unqualified imaging quality; 5. Severe comorbidities precluding chemotherapy or surgery; 6. Any other conditions deemed ineligible by the investigator.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| RCB0-1; | — |
Secondary
| Measure | Time frame |
|---|---|
| Objective Response Rate;Overall survival;Progression-Free Survival; | — |
Countries
China
Contacts
Public ContactSong Chuangui
Fujian Cancer Hospital
Outcome results
None listed