Stroke
Conditions
Interventions
Cerebellar iTBS combined with virtual reality lower limb exoskeleton robot group:Received conventional physical therapy and occupational therapy for 1 hour per day, 5 days per week, for a total of 4 w
Sham cerebellar iTBS combined with virtual reality lower limb exoskeleton robot group:received conventional physical therapy and occupational therapy, 1 hour per day, 5 days per week, for 4 weeks in t
Cerebellar iTBS combined with lower limb exoskeleton robot group:Patients received conventional physical therapy and occupational therapy for 1 hour per day, 5 days per week, lasting for 4 weeks. Mean
Sham cerebellar iTBS combined with lower limb exoskeleton robot group:Patients received conventional physical therapy and occupational therapy at 1 hour per day, 5 days per week, for a total of 4 week
Sponsors
Chinese PLA General Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Meet the diagnostic criteria for stroke updated in the 21st century, with a confirmed diagnosis of unilateral stroke verified by imaging examinations such as CT or MRI; 2.Aged between 18 to 80 years old; 3.First-ever and unilateral stroke onset; 4.Disease duration of 1 to 6 months after onset; 5.Stable vital signs; with no or mild cognitive impairment (MMSE score >= 21); able to cooperate with assessments and treatment procedures; 6.Lower limb Brunnstrom stage >= Stage III; 7. Lower limb Ashworth scale grade <= Grade 2; 8.No skull defect, cerebral edema or cerebral atrophy.
Exclusion criteria
Exclusion criteria: 1.Unstable medical condition or cognitive impairment that results in inability to cooperate with treatment; 2. Severe cardiopulmonary diseases, such as heart failure, myocardial infarction, asthma attack, acute exacerbation of chronic obstructive pulmonary disease, etc; 3. Other etiologies causing limb motor dysfunction (e.g., arthritis, lower limb ulceration, or other musculoskeletal diseases); 4.Contraindications to transcranial magnetic stimulation, such as intracranial metal implants, electronic implanted devices, and epilepsy; 5. Scalp damage, wounds or other conditions that preclude fNIRS examination; 6.Participation in other ongoing clinical research projects.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Fugl-Meyer Assessment for Lower Extremity; | — |
Secondary
| Measure | Time frame |
|---|---|
| Functional Ambulation Classification Scale Score;Berg Balance Scale Score;Barycentric value, slope value and mean value of changes in oxygenated hemoglobin;Root Mean Square; | — |
Countries
China
Contacts
Public ContactLiping Huang
Chinese PLA General Hospital
Outcome results
None listed