Liver Cirrhosis
Conditions
Interventions
Cirrhosis with NHHNs Cohort:None
Sponsors
China-Japan Union Hospital of Jilin University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–80 years 2. Clinically, laboratorily, radiologically, or pathologically confirmed liver cirrhosis. 3. Baseline multi-parametric liver MRI showing at least one nodule meeting the definition of NHHNs (hypointense on hepatobiliary phase, without typical arterial hyperenhancement). 4. Able to understand and voluntarily sign the written informed consent and commit to comply with the study’s follow-up schedule.
Exclusion criteria
Exclusion criteria: 1. History of primary liver malignancies other than HCC or any active malignancy in other organs. 2. Severe cardiovascular, pulmonary, renal, or neurological diseases, or other serious comorbidities that may significantly affect survival or follow-up compliance. 3. Pregnant or lactating women. 4. Estimated glomerular filtration rate (eGFR) < 30 mL/min/1.73 m² or acute kidney injury. 5. Child-Pugh class C liver function. 6. Contraindications to MRI examination or gadolinium-based contrast agents. 7. Assessed by investigators as unlikely to comply with study procedures or unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hypervascular transformation of NHHNs; | — |
Countries
China
Contacts
Public ContactMengchao Zhang
China-Japan Union Hospital of Jilin University
Outcome results
None listed