Helicobacter pylori Infection
Conditions
Interventions
Sponsors
Xiangya Hospital Central South University
Eligibility
Sex/Gender
All
Age
60 Years to 70 Years
Inclusion criteria
Inclusion criteria: Study participants must meet all of the following criteria to be eligible for inclusion in this study: 1.Elderly individuals aged 60-70 years; 2.Diagnosed with active H. pylori infection based on a positive result from any of the following tests: 13C or 14C urea breath test, rapid urease test, stool antigen test, or histological examination; 3.Conscious and mentally competent study participants who are legally and independently capable of understanding and signing the study informed consent form.
Exclusion criteria
Exclusion criteria: Study participants who meet any of the following criteria will be excluded from the study: 1.Known or previously documented history of hypersensitivity to any component of the investigational drug regimens; 2.Use of proton pump inhibitors (PPIs) or potassium-competitive acid blockers (P-CABs) within 2 weeks prior to screening; 3.Use of bismuth agents or any antibiotics (including traditional Chinese medicine components with antimicrobial properties) within 4 weeks prior to screening; 4.Presence of acute upper gastrointestinal bleeding within 1 week; 5.History of gastrectomy; 6.Co-morbid malignant tumors, severe renal impairment (glomerular filtration rate < 30 mL/min/1.73m^2), severe hepatic impairment (Child-Pugh class C), or other severe systemic diseases; 7.Other conditions determined by the investigator to be unsuitable for study participation, such as major medical diseases or psychiatric disorders that impede the implementation or completion of the protocol treatment and/or interfere with follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Helicobacter pylori eradication rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| Medication adherence of study participants; | — |
Countries
China
Contacts
Public ContactXiaowei Liu;Yu Peng
Xiangya Hospital, Central South University
Outcome results
None listed