Osteoarthritis
Conditions
Interventions
A:Maintain the pre-admission oral hypoglycemic medication regimen (in cases of poor blood sugar control, use regular insulin for emergency treatment)
B:Stop taking oral hypoglycemic drugs and adopt the basal-bolus insulin regimen.
The total daily insulin dose is 0.5 U/kg. The basal insulin is half of the total dose, and the remaining half dose is e
C:Stop taking oral hypoglycemic drugs and adopt the sliding scale insulin regimen.
The insulin dosage will be adjusted according to the pre-established plan.
D:Stop taking oral hypoglycemic drugs and use
100mg sitagliptin combined with basal insulin therapy (the total daily insulin dose is 0.5U/kg, and the basal insulin is half of the total dose)
Sponsors
Sichuan University, West China Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.Patients who are admitted for the first-time TJA; 2.Blood glucose level is between 140 and 400 mg/dl; 3.Having a diabetes history of more than 3 months; 4.Aged between 18 and 80 years old; 5.Having received only dietary treatment before admission, and have received any oral hypoglycemic drugs or small-dose (daily dose less than 0.4 U/kg) insulin treatment before admission.
Exclusion criteria
Exclusion criteria: 1.No known history of diabetes; 2.Hyperglycemia requiring high-dose (daily dose >= 0.4 U/kg) insulin control for type 2 diabetes; 3.Cardiac surgery; 4.Clinically relevant liver disease or renal dysfunction (serum creatinine 3.0 mg/dL); 5.History of diabetic ketoacidosis and acidosis; 6.Pregnancy; 7.Any mental condition that prevents the subject from giving informed consent.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| postoperative fasting BG (FBG) ;postprandial BG (PBG) levels;Postoperative insulin resistance level;Hypoglycemia Occurrence frequency; | — |
Secondary
| Measure | Time frame |
|---|---|
| The number and dosage of patients who received insulin as a remedy;Wound complications (hematoma, incision fat liquefaction, superficial incision infection, etc.);Postoperative complications (such as prosthesis loosening, prosthesis-related infection, pneumonia, etc.); | — |
Countries
China
Contacts
Public ContactZongke Zhou
West China Hospital
Outcome results
None listed