Stroke
Conditions
Interventions
Health Control:None
Sponsors
Shanghai Fourth People's Hospital Affiliated to Tongji University
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Healthy volunteers - Inclusion criteria: (1) Age range: 18 - 90 years old. (2) No severe underlying diseases. (3) Able to tolerate MRI examination and free from MRI examination contraindications (such as claustrophobia, metal implants, etc.). 2. Acute stroke patients - Inclusion criteria: (1) Meet the diagnostic criteria for acute ischemic stroke, confirmed by clinical and conventional MRI (such as DWI). (2) Onset time within 24 hours to ensure capturing the blood-brain barrier changes in the acute phase. (3) Age range: 18 - 90 years old. (4) The patient or their family members can understand the research content and cooperate to complete the follow-up. (5) Able to tolerate MRI examination and free from MRI examination contraindications (such as claustrophobia, metal implants, etc.).
Exclusion criteria
Exclusion criteria: 1. History of central nervous system diseases (such as brain tumors, multiple sclerosis, severe brain trauma, etc.). 2. Recently received treatment that might affect the blood-brain barrier (such as certain chemotherapy drugs). 3. The image quality is poor and MR-VEXI analysis cannot be performed. 4. Unable to complete the T0-T3 follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Apparent Diffusion Coefficient-ROI;AXRBBB-ROI;Filter Efficiency-ROI;AXRBBB-White matter;AXRBBB-Grey matter;AXRBBB-Whole Brain;Blood biochemical indicators (red blood cells, hemoglobin); | — |
Secondary
| Measure | Time frame |
|---|---|
| mRs;Age;Gender;Baseline NIHSS Score;Volume of Lension Core;SBP;DBP; | — |
Countries
China
Contacts
Public ContactLuo Yu
Shanghai Fourth People's Hospital Affiliated to Tongji University
Outcome results
None listed