Respiratory failure
Conditions
Interventions
Extubation success group vs Extubation failure group:None
Sponsors
West China Hospital of Sichuan University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Adult patients aged >=18 years 2. Receiving invasive mechanical ventilation for >=24 hours 3. Meet spontaneous breathing trial (SBT) screening criteria, with the attending physician having decided to perform SBT 4. Written informed consent obtained from the patient or legally authorized representative;
Exclusion criteria
Exclusion criteria: 1. Technical factors precluding EIT monitoring (e.g., large-area chest burns, wound dressings, implantable cardioverter-defibrillator) 2. Severe neuromuscular diseases, including spinal cord injury at C4 level or above, myasthenia gravis, Guillain-Barré syndrome 3. Severe consciousness impairment with Glasgow Coma Scale (GCS) score <=8, not reversible by medication 4. Prior tracheostomy 5. Planned transfer to another hospital or withdrawal of active treatment within 24 hours after extubation 6. Pregnancy or breastfeeding 7. End-stage disease (expected survival <7 days) or receiving purely palliative care 8. Cardiac arrhythmias that significantly affect HRV analysis (e.g., persistent atrial fibrillation, frequent premature ventricular contractions);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence rate of weaning failure; | — |
Secondary
| Measure | Time frame |
|---|---|
| EIT parameters (GII, SDRVD, V-D difference ?Pendelluft, EELI);HRV(SDNN ?RMSSD HF LF LF/HF TP );Diaphragmatic ultrasound (DE, DTF, DCV); | — |
Countries
China
Contacts
Public ContactGuopeng Liang
West China Hospital of Sichuan University
Outcome results
None listed