Tumor
Conditions
Interventions
Propofol group (P group):Propofol 1.5 mg/kg IV bolus (slow injection in low BMI, lean body weight in obese) + Alfentanil 5 µg/kg
Ciprofol group (C group):Ciprofol 0.4 mg/kg IV bolus + Alfentanil 5 µg/kg
Remimazolam group (R group):Remimazolam 0.3 mg/kg IV bolus + Alfentanil 5 µg/kg
Sponsors
Yunnan Provincial Cancer Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-75 years. 2. ASA I-III. 3. BMI groups: (1) Low BMI group: 16.5 <= BMI < 18.5 kg/m^2 (2) Normal BMI group: 18.5 <= BMI < 24.0 kg/m^2 (3) Overweight and obese group: 24.0 kg/m^2 <= BMI < 40 kg/m^2 4. Sign informed consent form.
Exclusion criteria
Exclusion criteria: 1. Allergy to propofol, fospropofol, or benzodiazepines. 2. Severe cardiopulmonary dysfunction, severe liver or kidney dysfunction. 3. Communication disorders. 4. Presence of difficult airway risk (Mallampati classification grade IV). 5. Long-term use of sedatives or analgesics. 6. Morbid obesity (BMI > 40 kg/m^2).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cyclic fluctuations;Respiratory depression; | — |
Secondary
| Measure | Time frame |
|---|---|
| Anesthetic efficacy;Adverse reactions;Awakening quality; | — |
Countries
China
Contacts
Public ContactLi Shanshan
Yunnan Provincial Cancer Hospital
Outcome results
None listed