Postoperative delirium
Conditions
Interventions
Control group:After entering the operating room, equal-volume normal saline was infused via pump, and respiratory parameters were adjusted to maintain PaCO? 35–45 mmHg and pH 7.35–7.45.
Dexmedetomidine group:After entering the operating room, dexmedetomidine was infused at a loading dose of 0.5µg·kg-1(completed within 10 minutes), followed by continuous intraoperative infusion at 0.2
Permissive hypercapnia combined with dexmedetomidine group:After entering the operating room, dexmedetomidine was pumped at a dose of 0.5µg·kg-1 was infused over 10 minutes, then maintained with conti
Sponsors
Wuhu Second People's Hospital
Eligibility
Sex/Gender
All
Age
65 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Age: 65~75 years old 2. BMI: 18~30 kg/m^2 3. ASA classification: Grade I~III 4. Preoperative MMSE score >= 23 points 5. Non-acute vulnerable brain function (no onset within 3 months)
Exclusion criteria
Exclusion criteria: 1.Severe cardiovascular and cerebrovascular events within the latest 6 months 2.Psychiatric disorders, drug dependence, visual and hearing impairment 3.No primary school education received 4.Preoperative moderate to severe anemia (Hb < 90 g/L) 5.Preoperative arterial partial pressure of oxygen (PaO2) < 70 mmHg 6.Intracranial hypertension, hydrocephalus, brain tumor, etc. 7.Sinus bradycardia, atrioventricular block, sick sinus syndrome 8.Orthostatic hypotension, insufficient blood volume, long-term use of beta-blockers
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Incidence of POD at postoperative days 1–3;Alterations of the brain injury biomarker neuron-specific enolase (NSE) and the inflammatory cytokine interleukin-6 (IL-6); | — |
Secondary
| Measure | Time frame |
|---|---|
| Patients' regional cerebral oxygen saturation (rSO2), heart rate (HR), mean arterial pressure (MAP), pulse oxygen saturation (SpO2), end-tidal carbon dioxide partial pressure (PETCO2), arterial partial pressure of carbon dioxide (PaCO2);Intraoperative use of vasoactive drugs, intraoperative consumption of anesthetics, intraoperative fluid infusion volume, intraoperative blood loss, and postoperative adverse reactions; | — |
Countries
China
Contacts
Public ContactAo Li/Peng Zhang
Wuhu Second People's Hospital
Outcome results
None listed