None
Conditions
Interventions
Group M(Positive Control Group):morphine 10 mg
Group O?(Experimental Group 1):oliceridine 0.03 mg/kg
Group O?(Experimental Group 2):oliceridine 0.04 mg/kg
Group O?(Experimental Group 3):oliceridine 0.05 mg/kg
Sponsors
Heji Hospital Affiliated to Changzhi Medical College
Eligibility
Sex/Gender
Female
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: All patients met the criteria of ASA Grade ?~?, aged 18~60 years, with body weight 45~75 kg and BMI 18~28 kg·m?².
Exclusion criteria
Exclusion criteria: 1. Severe arrhythmias such as severe sinus bradycardia and atrioventricular block; 2. Hypertension or hypotension; 3. Cardiovascular diseases such as coronary artery disease and valvular heart disease; 4. Abnormal liver and renal function; 5. History of severe psychiatric or neurological diseases; 6. Long-term use of sedative and analgesic drugs; 7. Patients with a history of allergy to the study drugs.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Probability of postoperative nausea and vomiting; | — |
Secondary
| Measure | Time frame |
|---|---|
| Visual analogue scale;Mean artery pressure;Heart rate;Saturation of Peripheral Oxygen;Respiratory rate;frequency of intraoperative body movement;cases administered atropine and ephedrine;Cases of postoperative shivering;Ramsay score at 10 minutes after spontaneous eye opening;Cases of urinary retention;Number of cases with mask ventilation support over 3 minutes; | — |
Countries
China
Contacts
Public ContactHuifen Li
Heji Hospital Affiliated to Changzhi Medical College
Outcome results
None listed