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Preemptive Risk-stratified Individualized 6-Mercaptopurine dosing in pEdiatric Acute Lymphoblastic Leukemia (PRIME-ALL) Implementation Trial

Facilitating Implementation of Precision Medication Guidelines through Pharmaceutical Care: Strategy Development and Empirical Evidence For An Implementation Science Study Using the PEDALs Model

Status
Active, not recruiting
Phases
Unknown
Study type
Interventional
Source
ChiCTR
Registry ID
ChiCTR2600125885
Enrollment
Unknown
Registered
2026-06-01
Start date
2026-06-05
Completion date
Unknown
Last updated
2026-06-08

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

pediatric acute lymphoblastic leukemia

Interventions

pre-emptive pharmacogenetic testing group:In the 6-MP precision dosing regimen, pediatric hematology-oncology ward based clinical pharmacists deliver ward-based pharmaceutical care by helping clinicia

Sponsors

Fujian Children's Hospital
Lead Sponsor

Eligibility

Sex/Gender
All
Age
1 Years to 18 Years

Inclusion criteria

Inclusion criteria: 1. Participants involved in pediatric leukemia treatment and willing to be interviewed: (1) Pediatric hematology-oncology physicians; (2) Pediatric hematology-oncology ward-based clinical pharmacists; (3) Clinical laboratory physicians; (4) Representatives from third-party genetic testing companies; (5) Administrative staff from the hospital's medical insurance office; (6) Guardians of pediatric hematology-oncology patients. 2. Patients receiving preemptive pharmacogenetic testing: (1) Pediatric patients with newly diagnosed ALL who require treatment with 6-MP, aged 1-18 years; (2) Receiving at least one cycle of HD-MTX infusion and oral 6-MP treatment.

Exclusion criteria

Exclusion criteria: 1. Pediatric acute lymphoblastic leukemia patients with liver and kidney function exceeding 5 times of the baseline.

Design outcomes

Primary

MeasureTime frame
clinical outcome effectiveness;Reach;Adoption;Fidelity;Maintenance;

Countries

China

Contacts

Public ContactRong Hu

Fujian Children's Hospital

hurong23@alumni.sysu.edu.cn+86 591 8611 2173

Outcome results

None listed

Source: ChiCTR (via WHO ICTRP) · Data processed: Jun 11, 2026