None
Conditions
Interventions
Split-dose group:A split-dose regimen will be administered, with dosing on the afternoon before the examination and the morning of the examination day.
Single-dose group:A single-dose regimen administered on the morning of the examination day (D0) will be adopted.
Sponsors
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Eligibility
Sex/Gender
All
Age
60 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Age between >=60 years and <=80 years. 2. No cognitive or language/communication impairment. 3. Provide informed consent to participate in this study. 4. Outpatients meeting indications for colonoscopy. 5. ECOG Performance Status score <=2.
Exclusion criteria
Exclusion criteria: 1. Allergy to any component of the PEG-ASC preparation (e.g., polyethylene glycol, vitamin C, etc.). 2. Severe heart failure (NYHA class III–IV), chronic kidney disease stage 4–5, or requirement for dialysis. 3. Contraindications to colonoscopy, such as severe intestinal obstruction, perforation, or acute peritonitis. 4. Currently participating in another interventional clinical trial. 5. Inability to comply with study drug administration or follow-up (e.g., due to cognitive impairment).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Rate of adequate bowel preparation; | — |
Secondary
| Measure | Time frame |
|---|---|
| Proportion of patients who found the bowel preparation "good-tasting";Full-dose completion rate;Patient satisfaction;Full-dose completion rate;Polyp and adenoma detection;Segment scores and total score of the Boston Bowel Preparation Scale (BBPS);Polyp and adenoma detection;Willingness to retake;Sleep disruption;Withdrawal time;Incidence of adverse events; | — |
Countries
China
Contacts
Public ContactHong Zhu
Jiangsu Province Hospital (The First Affiliated Hospital with Nanjing Medical University)
Outcome results
None listed