Acute pancreatitis
Conditions
Interventions
Balanced salt group:Patients randomly assigned to the balanced salt group will make the maximum use of balanced salt solutions (lactate Ringer's solution, acetic acid Ringer's solution, and carbonate
Normal saline group:Patients randomly assigned to the normal saline group will use normal saline to the maximum extent for all intravenous fluid treatments before death, before discharge, or within 7
Sponsors
Zhejiang Provincial People's Hospital
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1.The symptoms and signs of acute pancreatitis based on abdominal pain suggest AP, serum amylase is at least three times the upper limit of normal, and/or there are characteristic imaging manifestations of AP on CT. 2. Within 48 hours after the onset of the disease; 3. Aged between 18 and 70; 4. SIRS or CRP>150mg/L was present at the time of enrollment
Exclusion criteria
Exclusion criteria: 1. Patients who are pregnant or breastfeeding at the time of registration; 2. Received percutaneous drainage or surgery before admission, or required early surgery due to abdominal syndrome, etc. 3. Patients who had undergone CRRT before admission; 4. Patients who require emergency CRRT upon admission (with life-threatening water, salt, and acid-base imbalances); 5. The patient presents with respiratory failure, severe systemic circulatory failure, coma or other irreversible dangerous symptoms, and is expected to die within 24 hours (systolic blood pressure < 90mmHg and serum pH< 7.0 under full fluid resuscitation and treatment with 25ml/min or higher doses of norepinephrine); 6. Patients with a known history of severe cardiovascular, respiratory, renal, liver, blood or immune diseases are defined as (1) having a New York Heart Association grade II heart failure, (2) active myocardial ischemia or (3) cardiovascular intervention within the past 60 days, (4) a history of liver cirrhosis or (5) chronic kidney disease with a creatinine clearance rate of less than 40 mL/min. Or (6) Chronic obstructive pulmonary disease that requires home oxygen therapy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Survival within 7 days without organ failure days; | — |
Secondary
| Measure | Time frame |
|---|---|
| No organ failure within 14 days and the number of days of survival;MAKE30;The proportion of patients requiring admission to the ICU;The number of days without an ICU within 30 days;There are no mechanical ventilation days within 30 days;The number of days without vasoactive drugs within 30 days;There are no days of renal replacement therapy within 30 days;New organ dysfunction occurred after enrollment;The SOFA2 score from day 1 to day 7;The incidence of pancreatic infection and necrosis (IPN) during admission; | — |
Countries
China
Contacts
Public ContactJianfeng Tu
Zhejiang Provincial People's Hospital
Outcome results
None listed