Mild cognitive impairment (MCI)
Conditions
Interventions
Intervention group:LLM-assisted embodied social robot-based just-in-time adaptive cognitive training, three sessions per week, approximately 45 to 60 minutes per session, for 24 weeks. The system dyna
Control group:Non-adaptive active cognitive training delivered via a tablet-based program, with the same frequency and duration as the intervention group: three sessions per week, approximately 45 to
Sponsors
School of Nursing and Rehabilitation, Shandong University
Eligibility
Sex/Gender
All
Age
60 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age 60 years or older; 2. Meeting Petersen's diagnostic criteria for mild cognitive impairment; 3. MoCA score between 18 and 25, with appropriate adjustment according to educational level; 4. Having sufficient language communication, hearing, and vision abilities to understand study instructions and complete assessments and training; 5. Living in a community or home setting and able to participate in the 24-week cognitive training program as required; 6. Written informed consent provided by the participant or his/her legal representative or family member.
Exclusion criteria
Exclusion criteria: 1. Diagnosis of Alzheimer's disease or other forms of dementia; 2. Severe or unstable psychiatric disorders; 3. Contraindications to MRI, such as implanted metallic devices or severe claustrophobia; 4. Severe physical disability preventing participation in robot-based interaction or cognitive training; 5. Participation in other cognitive intervention clinical trials during the study period; 6. Other conditions judged by the investigators as unsuitable for participation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Montreal Cognitive Assessment (MoCA) total score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Domain-specific cognitive functions (including memory, attention, executive function, language, and orientation);Emotional states (including relevant scales or clinical assessment indicators for depression, anxiety, apathy, etc.);Motivation and engagement (including training participation, task completion, subjective experience, and technology acceptance);Compliance (including actual training frequency, completion rate, number of interruptions, and reasons for withdrawal);Safety (including fatigue, dizziness, emotional discomfort, device-related risks, privacy and data security incidents, etc.);Mechanistic subgroup indicators (resting-state functional MRI functional connectivity, brain network indicators, and changes in blood biomarkers); | — |
Countries
China
Contacts
Public ContactYingjuan Cao
School of Nursing and Rehabilitation, Shandong University
Outcome results
None listed