None
Conditions
Interventions
Etomidate group:Conventional anesthesia induction: pivalofloxetan hydrochloride 0.1mg/kg, etomidate 0.3mg/kg, sufentanil 0.3ug/kg, cisatracurium 0.1mg/kg. After the operation, sufentanil 0.1ug/kg was
Etomidate combined with esketamine group:Before anesthesia induction, 0.3mg/kg of esketamine was administered, followed by routine anesthesia induction with pivalofluoramine hydrochloride at 0.1mg/kg,
Sponsors
Anhui Provincial Children's Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 17 Years
Inclusion criteria
Inclusion criteria: 1) Age <= 17 years old, gender not restricted; 2) Planned to undergo elective ophthalmic surgery under general anesthesia; 3) ASA score I - III; 4) Guardian voluntarily signs the informed consent form
Exclusion criteria
Exclusion criteria: 1) The patient is expected to be hospitalized for less than 48 hours; 2) Patients who are expected to be admitted to the ICU after surgery; 3) Patients who are expected to return to the ward with an endotracheal tube after surgery; 4) Patients known to be allergic to the active ingredient or excipient of the eszopiclone hydrochloride injection; 5) Patients known to have adrenal insufficiency; 6) Patients with severe consciousness disorders or mental disorders (schizophrenia, mania, bipolar disorder, mental confusion, etc.) and cognitive dysfunction; 7) Children with congenital heart disease and those with severely delayed growth and development; 8) Patients with any of the following contraindications for the use of eszopiclone injection: 1. Patients with a high risk of severe hypertension or intracranial pressure elevation; 2. Patients with high intraocular pressure (glaucoma) or penetrating ocular trauma; 3. Patients with poorly controlled or untreated hypertension (arterial hypertension, resting systolic blood pressure exceeding 180 mmHg, or resting diastolic blood pressure exceeding 100 mmHg); Patients with untreated or inadequately treated hyperthyroidism (hyperthyroidism);
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| FLACC/NRS pain score;The consumption of opioid drugs within 48 hours after the operation;PGE2;5-HT;NPY;The period from the end of the surgery to the time of the first administration of rescue analgesic drugs after the operation;The rate of emergency pain relief within 48 hours after surgery;Anesthesia recovery time;The incidence of emergency delirium;Incidence of adverse events during surgery;The incidence of postoperative adverse events;Pharmaceutical economics indicators; | — |
Countries
China
Contacts
Public ContactXu Yuanling
Anhui Provincial Children's Hospital
Outcome results
None listed