Depression Disorder
Conditions
Interventions
Experimental group:Essential oil working solution
Control group:Distilled Water
Sponsors
Hebei Province Mental Health Center
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Aged between 18 and 60 years, regardless of gender; with an educational level of primary school or above; able to understand and comply with trial instructions. 2.Meets the diagnostic criteria for depressive disorders according to the DSM-5, with a 17-item Hamilton Depression Rating Scale (HAMD-17) score ranging from 8 to 24. 3.Normal olfactory function, capable of accurately identifying common odors (e.g., alcohol, vinegar). 4.Currently receiving treatment with a single class of antidepressant medication (SSRIs); must maintain the original dosage regimen after enrollment without switching to other medication classes. 5.During the study period, participants must maintain their original antidepressant treatment plan. Short-term use of sedative or hypnotic medications is permitted only for symptoms of insomnia. 6.Voluntary participation; willing to complete the 30-day trial procedure; guarantees effective nightly olfactory stimulation for more than eight hours; and has signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1.Olfactory dysfunction:? Individuals with severe rhinitis, sinusitis, nasal polyps, or those experiencing nasal congestion due to the common cold, hyposmia/anosmia during the trial period; as well as those with a long-term history of using essential oils for mood regulation. 2.History of allergies:? Known allergy to lavender, bergamot, or chamomile essential oils; or known allergic reactions to the materials used in the trial equipment (e.g., face masks, EEG caps). 3.Physical or psychiatric disorders:? Individuals diagnosed with epilepsy, severe asthma, cardiovascular and cerebrovascular diseases, diabetes, or other serious physical illnesses; or those with schizophrenia, bipolar disorder, or other severe psychiatric disorders; or those currently in the acute phase or a severe state of depressive disorder (HAMD-17 score > 24). 4,.Special populations:? Women who are planning pregnancy, pregnant, or breastfeeding; individuals who have participated in similar olfactory/emotional intervention trials within the past three months. 5.Inability to cooperate:? Individuals with cognitive impairment or communication barriers, or those unable to complete trial tasks as required, such as olfactory intervention during sleep or data collection. 6.Suicidal tendency:? Individuals with a suicidal tendency, defined as a score <=1 on Item 3 of the HAMD-17.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| HAMD-17;Resting Electroencephalogram;micro-expression;Self-assessment of subjective emotions in the morning; | — |
Countries
China
Contacts
Public ContactZhang Yunshu
Hebei Province Mental Health Center
Outcome results
None listed