Post-traumatic Stress Disorder
Conditions
Interventions
Phase 2 Control group (EMDR only):Eye Movement Desensitization and Reprocessing
Phase 2 Experimental group (EMDR+TMR):Eye Movement Desensitization and Reprocessing combined with REM sleep Targeted Memory Reactivation
Sponsors
Beijing Huilongguan Hospital, Capital Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 45 Years
Inclusion criteria
Inclusion criteria: Patient Inclusion Criteria: 1. Meet the diagnostic criteria for post-traumatic stress disorder in the International Classification of Diseases, 11th Revision (ICD-11); 2. Meet the diagnostic criteria according to the Clinician-Administered PTSD Scale for DSM-5 (CAPS-5) – Past Month version; 3. Aged 18–45 years; 4. Agree to participate in this study and sign the informed consent form. Control Group Inclusion Criteria: 1. Do not meet the diagnostic criteria for any mental disorder in ICD-11; 2. Matched with the patient group on age and education level; 3. Aged 18–45 years; 4. Agree to participate in this study and sign the informed consent form.
Exclusion criteria
Exclusion criteria: Patient Exclusion Criteria: 1. Presence of bipolar disorder, moderate to severe alcohol use disorder, or substance use disorder as assessed by the MINI International Neuropsychiatric Interview; 2. Use of benzodiazepines or other sleep medications from one week before the study start through the end of the study period; 3. Consumption of alcohol or coffee during the experiment; 4. Presence of suicidal or self-harm ideation; 5. History of neurological disease or recent severe head trauma with loss of consciousness; 6. Irregular sleep/wake rhythm (e.g., night shift, jet lag) or sleepwalking; 7. Participation in other non-pharmacological treatments such as repetitive transcranial magnetic stimulation, modified electroconvulsive therapy, or cognitive behavioral therapy within the past three months or currently ongoing. Control Group Exclusion Criteria: 1. Organic brain disease or history thereof; 2. Severe or unstable cardiovascular, hepatic, renal, endocrine, hematological, or other diseases; 3. Any mental disorder or risk of seizures; 4. History of suicide attempt or self-harm ideation; 5. Substance dependence; 6. Irregular sleep/wake rhythm (e.g., night shift, jet lag) or sleepwalking; 7. Presence of metal or electronic implants or other contraindications for MRI; 8. Women who are pregnant, lactating, or planning pregnancy.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Objective sleep architecture parameters by PSG;Change in clinician-assessed PTSD symptoms (CAPS-5 total score); | — |
Secondary
| Measure | Time frame |
|---|---|
| Resting-state fMRI functional connectivity of brain networks;Subjective sleep quality and related symptom scale scores;Resting-state EEG spectral features;Change in self-reported PTSD symptoms (PCL-C total score);Pre-post changes in brain network functional connectivity;REM sleep characteristics on intervention night; | — |
Countries
China
Contacts
Public ContactXiaohong Li
Beijing Huilongguan Hospital, Capital Medical University
Outcome results
None listed