Respiratory Depression
Conditions
Interventions
Tegileridine group:Administer different concentrations of tegileridine intravenously
Sponsors
Affiliated Hospital of Qingdao University
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 18-65 years old; 2. The American Society of Anesthesiologists (ASA) grades I-?; 3. Patients scheduled for surgery who require opioid analgesia postoperatively; 4. BMI within the normal or overweight range; 5. Voluntarily participate in the experiment and sign an informed consent form.
Exclusion criteria
Exclusion criteria: 1. Individuals with known hypersensitivity tegileridine or opioid medications; 2. Patients with severe hepatic or renal impairment; 3. Patients with respiratory dysfunction, including difficult airways, chronic obstructive pulmonary disease (COPD), or sleep apnea syndrome; 4. Pregnant or lactating women; 5. Individuals with opioid dependence or a history of prolonged opioid use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Respiratory rate;ED05; | — |
Secondary
| Measure | Time frame |
|---|---|
| Blood oxygen saturation;End-tidal carbon dioxide partial pressure;Blood Pressure;Nausea ;vomiting;dizziness; | — |
Countries
China
Contacts
Public ContactZejun Niu
Affiliated Hospital of Qingdao University
Outcome results
None listed