Hyperuricemia
Conditions
Interventions
Active Pediococcus acidilactici Group:Active Pediococcus acidilactici at a dose of 2 x 10^10 CFU, once daily, one sachet per dose (1g/sachet)
Inactivated Pediococcus acidilactici Group:Inactivated Pediococcus acidilactici at a dose of 2 x 10^10 AFU, once daily, one sachet per dose (1g/sachet)
Sponsors
The Second Affiliated Hospital of Xi’an Jiaotong University
Eligibility
Sex/Gender
All
Age
18 Years to 70 Years
Inclusion criteria
Inclusion criteria: 1) Age 18 to 70 years, with a male proportion of no less than 30%. 2) Serum uric acid (SUA) >= 480 µmol/L at screening, and SUA >= 420 µmol/L at a subsequent test with an interval of at least 24 hours.
Exclusion criteria
Exclusion criteria: 1) Inability to consume oral food or comply with the prescribed intake of the study product; 2) Inability to provide clear and coherent self-reports; 3) Women who are pregnant, lactating, or planning to conceive during the study; 4) History of allergies or known hypersensitivity to the study product ingredients; 5) Diagnosed with gout or presence of tophi; 6) Gastrointestinal surgery within the past 30 days, or antibiotic treatment within the past 30 days (excluding topical or genital medications); 7) Inpatients or individuals with acute gastrointestinal diseases within the past 2 weeks; 8) Severe comorbid diseases of the heart, liver, kidney, or hematopoietic system; psychiatric disorders; patients with diabetes ongoing insulin treatment; or BMI > 35 kg/m^2; 9) Regular consumption of probiotic products within the past 30 days (more than 3 times per week), or use of medications affecting serum uric acid within the past 2 weeks (e.g., thiazide/loop diuretics, quinolones, aspirin); 10) Abnormal liver or kidney function indicators; 11) Use of urate-lowering drugs (e.g., Allopurinol, Febuxostat, Benzbromarone) within the past 3 months prior to intervention; 12) High-purine dietary habits (intake of animal viscera, seafood, or thick meat broth > 5 times per week) or habitual alcohol consumption (average daily alcohol intake > 25g); 13) Individuals deemed unsuitable for participation by the investigator; 14) Failure to sign the Informed Consent Form.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Serum uric acid;Triglycerides;Total cholesterol;HDL-C;LDL-C;High-sensitivity C-reactive protein, hs-CRP;IL-6;Gut Microbiome; | — |
Secondary
| Measure | Time frame |
|---|---|
| Glocose;Allantoin; | — |
Countries
China
Contacts
Public ContactXin Liu; Qian Wang
The Second Affiliated Hospital of Xi'an Jiaotong University
Outcome results
None listed