Uncontrolled hypertension
Conditions
Interventions
Renal artery sympathetic denervation group:Renal denervation
Hepatic and renal artery combined with sympathetic denervation group:Combined hepatic and renal artery denervation
Sponsors
The First Affiliated Hospital of Chengdu Medical College
Eligibility
Sex/Gender
All
Age
18 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Aged from 18 to 65 years old; 2. Have taken antihypertensive drugs within the past 6 months with uncontrolled blood pressure; 3. Meet the diagnostic criteria of essential hypertension, with office systolic blood pressure >=150 and =90 mmHg, and with uncontrolled blood pressure after standard drug treatment (>=2 antihypertensive drugs used in sufficient doses) for more than 1 month, or unable to tolerate drug treatment; 4. After standard antihypertensive treatment, 24-hour mean ambulatory systolic blood pressure =130mmHg or daytime mean ambulatory systolic blood pressure >=135mmHg; 5. The anatomical structure of common hepatic artery and renal artery was suitable for ablation (vessel diameter 3-8 mm); 6. Clear consciousness, able to cooperate to complete the follow-up and sign the informed consent.
Exclusion criteria
Exclusion criteria: 1. History of acute myocardial infarction, acute heart failure, stroke 3 times upper limit of normal, eGFR50%, hepatic artery malformation or severe calcification; 4. Coagulation dysfunction or the use of anticoagulant drugs can not be stopped; 5. Pregnant or lactating women; 6. People with mental disorders or intellectual disabilities who are unable to make independent decisions; 7. Participating in other clinical studies that have not been completed.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Office blood pressure;24-hour ambulatory blood pressure; | — |
Secondary
| Measure | Time frame |
|---|---|
| Use of antihypertensive drugs;Kidney function;Liver function ;Heart rate;plasma catecholamine; | — |
Countries
China
Contacts
Public ContactWang Peijian
The First Affiliated Hospital of Chengdu Medical College
Outcome results
None listed