None
Conditions
Interventions
Low-dose group:Dexmedetomidine 50 micrograms administered by nasal spray
High-dose group:Dexmedetomidine 100 micrograms administered by nasal spray
Sponsors
Suzhou Municipal Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age over 65 years old, with the same surgical and anesthesia team performing the surgery and anesthesia procedures; 2. American Society of Anesthesiologists (ASA) classification: I-III grade; 3. First-time spinal anesthesia for unilateral total hip or total knee arthroplasty; 4. No use of a2 receptor agonists in the past month.
Exclusion criteria
Exclusion criteria: 1. The patient has undergone multiple same-side total hip or total knee joint replacements; 2. Emergency surgery patients; 3. Missing clinical data; 4. Having severe internal medical conditions, such as liver and kidney dysfunction; 5. History of nasal surgery or diseases, such as rhinitis, nasal polyps and sinusitis; 6. Sinus bradycardia and atrioventricular block; 7. Coagulation dysfunction or history of lumbar spine surgery, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Ramsay Sedation Score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Self-rating Anxiety Scale (SAS) score;CAM scale score; | — |
Countries
China
Contacts
Public ContactChengyong Gu
Suzhou Municipal Hospital
Outcome results
None listed