Intestinal Surgery
Conditions
Interventions
Propofol Group:Propofol
Sponsors
Sun Yat-sen University Cancer Center
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Elderly patients aged 65 or above (regardless of gender). 2. Scheduled for elective intestinal surgery and planned to undergo general anesthesia. 3. The estimated operation duration is >= 2 hours. 4. ASA classification is I–III. 5. Preoperative cognitive function is normal (MoCA score >= 26 falls within the normal range). 6. Able to understand and cooperate with cognitive function tests and follow-up evaluations (,). 7. No significant abnormalities in important organs such as heart, lungs, liver, and kidneys (can be excluded as having severe functional impairment through clinical assessment and routine examinations). 8. The patient and their family have given informed consent to participate in this study and have signed a written informed consent form.
Exclusion criteria
Exclusion criteria: 1. Patients with a previous diagnosis of cognitive impairment, dementia or mental illness; those identified with significantly impaired cognitive function during preoperative screening. 2. Complicated with severe central nervous system diseases (such as Parkinson's disease, post-stroke sequelae, uncontrolled epilepsy, etc.). 3. Long-term use of psychotropic drugs (sedative-hypnotics, antipsychotics or opioids, etc.), or with a history of alcohol or drug dependence. 4. Complicated with severe depression, schizophrenia or other mental disorders, which may affect perioperative cooperation and assessment of patients. 5. Severe visual or language disorders, unable to cooperate in completing cognitive assessment. 6. Allergic constitution or known allergies to propofol, etomidate and emulsifier components. 7. Extremely abnormal BMI (such as > 35 or < 18 kg/m^2) or conditions with airway management difficulties that may increase anesthesia risks (judged by the researcher based on specific circumstances). 8. Other situations that the researchers consider unsuitable for participating in this study (such as combined with uncontrollable severe heart and lung diseases, extremely unstable preoperative hemodynamics, etc.).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of postoperative cognitive dysfunction (POCD).; | — |
Secondary
| Measure | Time frame |
|---|---|
| The incidence of delirium.;Evaluation of anesthetic effect;Awakening time;Postoperative pain NRS score;Postoperative sleep NRS score;Postoperative recovery quality scale score;Incidence of perioperative adverse reactions; | — |
Countries
China
Contacts
Public ContactWan Huang
Sun Yat-sen University Cancer Center
Outcome results
None listed