Portal hypertension
Conditions
Interventions
Stepwise TIPS:stepwise TIPS
Control group:Standard diameter TIPS
Sponsors
Zhongshan hospital,Fudan university
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18–75 years, with no gender restriction; 2. Clinically or pathologically confirmed diagnosis of cirrhotic portal hypertension, with a prior history of endoscopically confirmed esophagogastric variceal rupture and recurrent bleeding after receiving standard therapy; 3. The patient and their family members have agreed to participate in the clinical trial and have signed the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Severe liver failure: Child-Pugh score > 12 or MELD score > 19; 2. Prior history of hepatic encephalopathy (HE): recurrent spontaneous overt HE within 3 months before the procedure; 3. Malignancy: concomitant hepatocellular carcinoma (HCC) beyond the Milan criteria or other malignancies with an expected survival < 12 months; 4. Severe cardiac or renal dysfunction: New York Heart Association (NYHA) class III–IV heart failure, moderate-to-severe pulmonary hypertension, or uncontrolled renal failure; 5. Portal vein thrombosis (PVT): cavernous transformation of the portal vein or extensive PVT precluding the establishment of an interventional access; 6. Anatomical abnormalities: severe anatomical variations of the intrahepatic vasculature making TIPS unsuitable; 7. Psychiatric disorders: inability to accurately assess neuropsychiatric status; 8. Prior surgical treatment for portal hypertension: history of surgical shunt, devascularization, or splenectomy; 9. Previous TIPS or liver transplantation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Overt hepatic encephalopathy ; | — |
Countries
China
Contacts
Public ContactJianjun Luo
Zhongshan hospital,Fudan university
Outcome results
None listed