Male infertility
Conditions
Interventions
SLS-IMSI Group:Perform Intracytoplasmic morphologically-selected sperm injection with ultra-high magnification after single-layer strip sperm spread processing of the semen
ICSI Group:Perform conventional intracytoplasmic sperm injection with sperm selected under 200-400x magnification
Sponsors
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
22 Years to 45 Years
Inclusion criteria
Inclusion criteria: 1. Male partners aged 22-45 years, diagnosed with severe oligozoospermia (total sperm count: 0.1-5.0 × 10^6 per entire sample); 2. Female partners aged =5, AMH >=1.2 ng/mL); 3. Number of mature (MII) oocytes obtained in the current cycle >=6; 4. The study participant and his/her spouse have provided signed informed consent.
Exclusion criteria
Exclusion criteria: 1. Presence of other well-defined oocyte-related factors contributing to infertility (e.g., oocyte maturation disorder); 2. Presence of definite uterine anomalies (e.g., septate uterus, unicornuate uterus); 3. Presence of contraindications to pregnancy or assisted reproductive technology; 4. Presence of symptoms of urinary tract infection.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| blastocyst formation rate; | — |
Secondary
| Measure | Time frame |
|---|---|
| 2PN fertilization rate;Day 3 good-quality embryo rate;D5 good-quality blastocyst formation rate;good-quality blastocyst formation rate;available blastocyst rate;biochemical pregnancy rate;clinical pregnancy rate;implantation rate;miscarriage rate;live birth rate;cumulative live birth rate; | — |
Countries
China
Contacts
Public ContactHe Xiaojin
Shanghai General Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed