Postoperative delirium
Conditions
Interventions
POD Group vs Non-POD Group:None
Sponsors
Handan First Hospital
Eligibility
Sex/Gender
All
Age
65 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Age >=65 years; 2. American Society of Anesthesiologists (ASA) classification II~III.
Exclusion criteria
Exclusion criteria: 1. Long-term use of opioids, sedatives, antidepressants, or anti-anxiety drugs before surgery; 2. Inability to communicate normally before surgery; 3. Preoperative Mini-Mental State Examination (MMSE) score less than 26; 4. Received anesthesia or surgery within the past 30 days; severe heart failure; 5. Severe chronic obstructive pulmonary disease; 6. Patients with concomitant infectious diseases or abnormal preoperative inflammatory markers; 7. Patients with significant liver and kidney dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| GPNMB;Demographic characteristics and perioperative-related data: age, sex, educational level, ASA classification, BMI, ACCI, smoking history, alcohol consumption history, MMSE;; | — |
Secondary
| Measure | Time frame |
|---|---|
| IL-1ß;IFN-?;TNF-a;Preoperative laboratory test indicators: blood glucose, ejection fraction, Hb, white blood cell count, C-reactive protein, albumin, serum creatinine, total cholesterol, glomerular filtration rate, blood urea nitrogen, erythrocyte sedimentation rate, D-dimer;;Intraoperative data: operation time, blood loss, propofol dosage, and occurrence of intraoperative hypotension; postoperative data include postoperative NRS scores;; | — |
Countries
China
Contacts
Public ContactSong Huayong
Handan First Hospital
Outcome results
None listed