Autism Spectrum Disorder
Conditions
Interventions
Observation group:None
Sponsors
Alice Ho Miu Ling Nethersole Charity Foundation
Eligibility
Sex/Gender
All
Age
1 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1 Reported by parents to be autistic or ASD with confirmation from health care professional workers. The probands must have received a valid and reliable assessment and must meet cutoffs for autism spectrum or autism. (E.g. The newest ADOS algorithms to be used for Modules 1 - 3 and the original cutoff algorithms to be used for Module 4; or a clinical "Best Estimate Diagnosis," of Autistic Disorder, Asperger’s Disorder, or PDD-NOS, according to the ADOS or DSM-IV-TR or DSM-5 or DSM-5-TR). 2 Age: The proband that age between 1 and 18 years old, their parents and any first-degree relatives (autistic or not) will also be recruited in anticipation that these samples will be valuable resources for further understanding of the genetic factors that might contribute to the phenotype. 3 Being ethnic Chinese
Exclusion criteria
Exclusion criteria: 1 With significant injury, abnormality, or disease having effects upon the brain, extensive complications during birth or pregnancy (careful screening will be carried out for those who stayed in the hospital for more than 3 days after birth). 2 With significant nutritional and psychological deprivation*. 3 Other known genetic disorders: e.g. Down's syndrome, or Fragile X syndrome. 4 Those diagnosed with a known genetic disorder, and those with a psychiatric disorder require medication.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| specific structural variations in MAU2 and ZFHX3, along with other structural variants (SVs), within the ASD patient population; | — |
Countries
China
Contacts
Public ContactChair Sek Ying
The Nethersole School of Nursing, The Chinese University of Hong Kong
Outcome results
None listed