Type 2 diabetes with obesity
Conditions
Interventions
Experimental group:All patients were provided with a diabetic diet and lifestyle management, with insulin therapy administered based on blood glucose levels. Sangzhi Total Alkaloid Tablets were prescr
after one month, the dose was adjusted to 100mg per dose, three times daily, taken with meals
Control group:All patients were given diet and lifestyle management for diabetes, and insulin therapy was applied according to blood sugar,Metformin tablets, 500 mg/time, three times a day, taken oral
Sponsors
Capital Medical University Affiliated Capital Children's Medical Center
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Meets the diagnostic criteria for pediatric T2DM; 2. Age range: 10 to 18 years old; 3. Poor blood sugar control (HbA1c above 6.5%); 4. BMI exceeding the 85th percentile for children of the same age and gender; 5. ALT/AST = 60 mL/min/1.73m²;R1: "Diabetes" must be translated as diabetes. 6. No episodes of diabetic ketoacidosis or severe hypoglycemia (blood glucose <3.0 mmol/L with symptoms) in the past 1 month; 7. Guardians and subjects sign the informed consent form.
Exclusion criteria
Exclusion criteria: 1. Other types of diabetes (such as MODY, secondary diabetes); 2. Allergic or intolerant to alpha glucosidase inhibitors; 3. History of severe complications of diabetes; 4. Serious cardiovascular diseases and autoimmune diseases; 5. History of gastrointestinal diseases or pancreatic diseases; 6. Have used oral medications that affect blood sugar or weight in the past 3 months; 7. Chronic gastrointestinal dysfunction, significant digestive and absorption disorders, or endocrine disorders; 8. Participate in clinical trials of other drugs or medical devices within the first 3 months; 9. Unable to complete the expected treatment and follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Hemoglobin A1c; | — |
Secondary
| Measure | Time frame |
|---|---|
| Fasting blood glucose;fasting C-peptide;Fasting insulin;2-hour postprandial blood glucose;Oral glucose tolerance test;red blood cell count;Hemoglobin;Platelet count;white blood cell count;Neutrophil count;Lymphocyte count;Total protein;Albumin;Creatinine;Urea nitrogen;Alkaline phosphatase;Total bilirubin;Direct bilirubin;Alanine aminotransferase (ALT);Aspartate aminotransferase;Lactate dehydrogenase;uric acid;urinary white blood cells;liver ultrasound;glycosuria;occult blood in urine;Red blood cells in urine;proteinuria;ketone bodies;Urinary microalbumin;Total Cholesterol;triglyceride;High density lipoprotein;Low density lipoprotein; | — |
Countries
China
Contacts
Public ContactCao Bingyan
Beijing Children's Hospital, Capital Medical University
Outcome results
None listed