depression
Conditions
Interventions
Experimental group:Antidepressant combined with Saccharomyces boulardii treatment
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 55 Years
Inclusion criteria
Inclusion criteria: 1.Meets the diagnostic criteria for depression according to ICD-11, aged 18-55 years old; 2.No antidepressant medication has been taken in the past three months, and no probiotic preparations or antibiotics have been taken in the past month; 3.No significant organic disease; 4.Capable of cooperating in completing scale assessments and collecting blood and fecal specimens; 5.Voluntarily participate and sign the informed consent form; 6.Combined with gastrointestinal discomforts such as abdominal distension and diarrhea;
Exclusion criteria
Exclusion criteria: 1.Individuals with brain organic diseases or other mental and psychological disorders such as schizophrenia, bipolar disorder, or mania; 2.Individuals with intestinal diseases such as peptic ulcer, inflammatory bowel disease, or colorectal cancer, or those who have undergone gastrointestinal surgery within the past 6 months; 3.Women who are in gestation period, within one year after childbirth, or in lactation period; 4.Malignant tumor, undergoing radiotherapy and chemotherapy, or history of other severe diseases; 5.Individuals with severe cognitive dysfunction who are unable to complete scale assessments and related tests; 6.Individuals with lactose intolerance, as well as those allergic to milk protein and yeast;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| anxiety score;Depression score; | — |
Secondary
| Measure | Time frame |
|---|---|
| Short-chain fatty acids (SCFAs);sleep quality;Brain-derived neurotrophic factor(BDNF);cognitive function;Gut microbiota;inflammatory factors;social function;Overall clinical efficacy evaluation;side reaction; | — |
Countries
China
Contacts
Public ContactLiu Fang
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed