Metabolically associated fatty liver disease
Conditions
Interventions
Control Group:None
Sponsors
First Affiliated Hospital of Kunming Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Imaging diagnosis of fatty liver; 2. BMI >= 24 kg/m^2, or waist circumference >= 90 cm (male) and 85 cm (female), or excessive body fat content and body fat percentage; 3. Fasting blood glucose >= 6.1 mmol/L, or 2-hour post-load blood glucose >= 7.8 mmol/L or HbA1c >= 5.7%, or history of type 2 diabetes, or insulin resistance index >= 2.5; 4. Fasting serum triglycerides >= 1.7 mmol/L, or currently receiving lipid-lowering therapy; 5. Serum high-density lipoprotein = 130/85 mmHg, or currently receiving antihypertensive treatment.
Exclusion criteria
Exclusion criteria: 1.Excessive alcohol consumption: Weekly ethanol intake >= 210 g for males or >=140 g for females; 2.Other causes that may lead to fatty liver disease: viral hepatitis, autoimmune hepatitis, drug-induced liver injury, Wilson's disease, etc; 3.Concurrent systemic diseases: total parenteral nutrition, celiac disease, hyperthyroidism or hypothyroidism, Cushing's syndrome, acromegaly, anterior pituitary hypofunction, hypogonadism, etc; 4.History of using medications that affect insulin secretion or insulin sensitivity; 5.History of COVID-19 infection or prior confirmed diagnosis of COVID-19; 6.Subjects who are unable to cooperate with the study or have not provided signed informed consent;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| ACSS2 Gene Expression;ACSS2 Protein Expression;Assessment of Hepatic Steatosis and Fibrosis;Measurement of Biochemical Indicators; | — |
Secondary
| Measure | Time frame |
|---|---|
| General Patient Information; | — |
Countries
China
Contacts
Public Contactyushan Xu
First Affiliated Hospital of Kunming Medical University
Outcome results
None listed