Prostate cancer
Conditions
Interventions
Index test:[18F]FDG PET/CT imaging and ACP3-HKZ PET/CT imaging
Sponsors
Peking University Shenzhen Hospital
Eligibility
Sex/Gender
Male
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1. Research participants voluntarily participate in this study and sign an informed consent form. 2. Aged 18-75 years old (based on the date of signing the informed consent form). 3. The primary inclusion criteria for patients are a pathologically confirmed prostate cancer diagnosis or clinical manifestations and other imaging examinations indicating suspected prostate cancer that needs confirmation. 4. Expected survival time is more than 12 weeks. 5. Blood routine and liver and kidney function meet the following criteria: Blood routine: WBC >= 4.0 × 10^9/L or neutrophils >= 1.5 × 10^9/L, PLT >= 100 × 10^9/L, Hb >= 90 g/L; PT or APTT <= 1.5 ULN; Liver and kidney function: T-Bil <= 1.5 × ULN (upper limit of normal), ALT/AST <= 2.5 ULN or <= 5 × ULN, ALP <= 2.5 ULN (if there are bone or liver metastases, ALP <= 4.5 ULN); BUN <= 1.5 × ULN, SCr <= 1.5 × ULN. 6. Willing and able to comply with the diagnostic plan, clinical laboratory tests, and other study procedures.
Exclusion criteria
Exclusion criteria: 1.Critically ill emergency patients; severe respiratory failure or airway obstruction due to respiratory diseases. 2.Presence of contraindications to PET/CT scanning, including but not limited to: poorly controlled elevated blood glucose; known allergy to radiopharmaceuticals or their excipients (including a history of severe allergic or anaphylactic reactions, especially allergy to the study drug). 3.Patients who cannot tolerate or have not successfully completed previous clinical examinations. 4.Previous use of radionuclides with an interval of less than 10 physical half-lives before administration in this study. 5.Deemed unsuitable for participation in this study by the investigator. 6.Patients with a second primary tumor.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Specificity;Sensitivity;Accuracy; | — |
Countries
China
Contacts
Public ContactDong Mengjie
Peking University Shenzhen Hospital
Outcome results
None listed