Sepsis
Conditions
Interventions
Sponsors
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.ICU patients diagnosed with sepsis or septic shock; 3.A clinical decision was made to treat with vancomycin, and the expected treatment duration is =3 days. 4.Informed consent form has been signed.
Exclusion criteria
Exclusion criteria: 1.Allergy to fluorescent tracers (pyrazine derivatives) or related components. 2.History of photosensitive diseases; 3.Pregnant or breastfeeding women; 4.The skin at the monitoring site has large areas of damage or infection. 5.The researchers determined that participation was not suitable.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Compare the accuracy of tGFR and traditional eGFR in predicting the steady-state trough concentration of vancomycin in patients with sepsis; | — |
Secondary
| Measure | Time frame |
|---|---|
| The performance of tGFR in identifying enhanced renal clearance (ARC);The correlation between tGFR and individual vancomycin clearance rate; | — |
Countries
China
Contacts
Public ContactHongping Qu
Ruijin Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed