Septic shock
Conditions
Interventions
Exposed group:Anisodamine hydrobromide injection was used
Non-exposed group:Anisodamine hydrobromide injection had not been used
Sponsors
The Third Affiliated Hospital of Southern Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1.Age >=18 years old; 2.Meet the diagnostic criteria for septic shock (sepsis 3.0); 3.Within 48 hours of diagnosis of septic shock; 4.Sublingual microcirculation data could be monitored by handheld microcirculation imager during the study period; 5.Informed consent was obtained from patients or their legal representatives;
Exclusion criteria
Exclusion criteria: 1.Combined with other causes of shock (such as cardiogenic shock, hemorrhagic shock); 2.Patients treated with anisodamine within 48 hours before screening; 3.Predicted survival time <48 hours (such as end-stage disease, irreversible multiple organ failure); 4.Pregnant or lactating women; 5.Participating in other interventional clinical trials; 6.Patients whose sublingual microcirculation could not be measured; 7.Not suitable to participate in the study according to the investigator's judgment.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Microcirculatory Flow Index?(MFI); | — |
Secondary
| Measure | Time frame |
|---|---|
| Improvement rate of microcirculation;28 All-cause mortality rate;PVD (Perfusion Vessel Density);? POEM score: The differences between the measured values at 24h, 48h, 72h, and 96h after enrollment and the baseline values;The proportion and duration of mechanical ventilation and renal replacement therapy within 28 days;Total dose (in terms of methoxamine equivalent) of vasoactive drugs used within 28 days;The differences between the measured values at 24 hours, 48 hours, 72 hours and 96 hours after enrollment and the baseline values.;Capillary refill time (CRT);PPV(Perfused Vessel Proportion);Liquid net balance volume;TVD (Total Vascular Density);The number of days during which vasoconstrictor drugs were used within 28 days;POEM score;Blood lactate clearance rate; | — |
Countries
China
Contacts
Public ContactHong Yang
The Third Affiliated Hospital of Southern Medical University
Outcome results
None listed