Breast cancer
Conditions
Interventions
Esketamine combined with paravertebral nerve block group:Received ultrasound-guided paravertebral nerve block with ropivacaine after anesthesia induction, combined with intraoperative continuous infus
Esketamine group:Received ultrasound-guided paravertebral nerve block with an equivalent volume of normal saline after anesthesia induction, combined with intraoperative continuous infusion of esketam
Paravertebral block group:Received ultrasound-guided paravertebral nerve block with ropivacaine after anesthesia induction, combined with intraoperative continuous infusion of an equivalent volume of
Control group:Received ultrasound-guided paravertebral nerve block with normal saline after anesthesia induction, combined with intraoperative continuous infusion of an equivalent volume of normal sal
Sponsors
Affiliated hospital of north sichuan medical college
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Patients with ASA physical status I-III scheduled for elective unilateral modified radical mastectomy or breast-conserving radical mastectomy; 2. Including those undergoing unilateral total mastectomy; 3. Total mastectomy with axillary lymph node dissection; 4. Total mastectomy with sentinel lymph node biopsy; 5. Or breast-conserving surgery with axillary lymph node dissection.
Exclusion criteria
Exclusion criteria: 1. History of opioid use within 3 months prior to enrollment; 2. Previous surgery on the ipsilateral breast; 3. Allergy to local anesthetics or opioids; 4. Planned bilateral surgery; 5. History of major breast reconstruction involving tissue flaps; 6. Contraindications to regional anesthesia; 7. Male patients; 8. Pregnant or breastfeeding women; 9. Use of beta-blockers; 10. Receipt of other analgesic regimens; 11. Inability to comply with the study protocol for any reason.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quality of postoperative recovery; | — |
Secondary
| Measure | Time frame |
|---|---|
| Pain score;Serum levels of cortisol, epinephrine, IL-6, and TNF-a;Time to first ambulation;Postoperative hospital stay;Adverse events; | — |
Countries
China
Contacts
Public ContactZhao Yang
Affiliated hospital of north sichuan medical college
Outcome results
None listed