None
Conditions
Interventions
ES (Esketamine group):Esketamine combined with propofol
SF (Sufentanil Group):Sufentanil combined with propofol
RF (Remifentanil Group):Remifentanil combined with propofol
Sponsors
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Eligibility
Sex/Gender
All
Age
40 Years to 65 Years
Inclusion criteria
Inclusion criteria: 1. Age 40-65 years; 2. BMI 18-30 kg/m^2; 3. ASA classification I-III; 4. Elective therapeutic ERCP (expected duration >30 min);
Exclusion criteria
Exclusion criteria: 1. Severe cardiopulmonary disease (EF<40%, FEV1<50%), liver and kidney dysfunction (Child-Pugh class C, eGFR<30 ml/min); 2. Long-term history of opioid use; 3. Mental illness or cognitive impairment (MMSE<24); 4. Anticipated difficult airway; 5. Pregnant or breastfeeding women.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Inflammatory and stress markers;Intraoperative vital signs and drug dosage;Number of cases requiring intervention for incidence of motor response, coughing, hypotension, and respiratory depression;Operator satisfaction score; time to emergence, time to orientation recovery;Intraoperative parameters; | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of postoperative mental symptoms such as nausea, vomiting, and hallucinations;Postoperative Cognitive Function Scale;Patient demographics;Postoperative Recovery Scale;24-hour postoperative quality of recovery score; | — |
Countries
China
Contacts
Public ContactCai Qiang
The First Affiliated Hospital of the Baotou Medical College of Inner Mongolia University of Science and Technology
Outcome results
None listed