Cesarean delivery
Conditions
Interventions
Experimental Group:After confirming proper placement of the catheter in the epidural space without abnormalities, the experimental group received an intravenous bolus of 10ml of anesthetic solution (0
Control Group:The control group underwent subarachnoid block at the L3–4 interspace with administration of 2ml of 0.5% bupivacaine hydrochloride (10mg).
Subgroup E1:In subgroup E1, 10 mL of anesthetic mixture (0.375% ropivacaine hydrochloride combined with 1% lidocaine hydrochloride) was injected into the epidural space, and 5 mg dexamethasone was adm
Subgroup E2:In subgroup E2, 10 mL of anesthetic mixture (0.375% ropivacaine hydrochloride + 1% lidocaine hydrochloride) was injected into the epidural space, and no dexamethasone was administered intr
Subgroup C1:In subgroup C1, subarachnoid block was performed at the L3-4 interspace with 2 mL of 0.5% bupivacaine hydrochloride (10 mg) administered, and 5 mg dexamethasone was injected intravenously
Subgroup C2:In subgroup C2, subarachnoid block was performed at the L3-4 interspace with 2 mL of 0.5% bupivacaine hydrochloride (10 mg) administered, and no dexamethasone was given intravenously prior
Sponsors
Nanjing Jiangning Hospital
Eligibility
Sex/Gender
Female
Age
22 Years to 40 Years
Inclusion criteria
Inclusion criteria: 1. Full-term primiparous women with a gestational age of 37–41 weeks who voluntarily request ELA; 2. ASA physical status ?–?, aged 22–40 years, body mass index (BMI) 20–35 kg/m², singleton cephalic presentation.
Exclusion criteria
Exclusion criteria: 1. Cases in which epidural analgesia fails and conversion to general anesthesia is required; 2. Cases requiring repeat puncture due to dislodgement of the epidural catheter; 3. Cases with failed subarachnoid puncture; 4. Fetuses complicated with intrauterine distress, developmental abnormalities or other conditions; 5. Subjects who refuse to participate in this study or cannot cooperate with postoperative follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Maternal Emotional Status Scales;Dosage of anesthetics and time required for parturients to meet surgical anesthesia requirements;Apgar scores of newborns at 1 and 5 minutes after birth; blood gas analysis indicators of umbilical artery immediately after delivery of newborns; fetal distress and neonatal asphyxia.;Maternal serum levels of stress hormones, pain mediators and inflammatory markers; | — |
Secondary
| Measure | Time frame |
|---|---|
| General vital signs of the parturients in the two groups were recorded respectively, including heart rate, pulse oxygen saturation, non-invasive blood pressure, etc.;Maternal adverse reactions;Routine blood test and biochemical indicators in parturients; | — |
Countries
China
Contacts
Public ContactZhao Jun
Nanjing Jiangning Hospital
Outcome results
None listed