Refractory Overactive Bladder (OAB)
Conditions
Interventions
Refractory OAB transurethral selective green laser vaporization Pre-post Intervention Study:None
Sponsors
Shandong Provincial Hospital
Eligibility
Sex/Gender
Female
Inclusion criteria
Inclusion criteria: 1.Unable to tolerate more than one anticholinergic drug, or ineffective after 3 months of anticholinergic drug treatment; 2.Adult female patients with overactive bladder who did not achieve the expected therapeutic effect after sacral nerve regulation, percutaneous tibial nerve stimulation or intramural botulinum toxin type A injection.
Exclusion criteria
Exclusion criteria: 1. Combined with mental illness or severe physical illness; 2. Combined with bladder outlet obstruction; 3. Concurrent urinary tract infections, calculi and other urological diseases; 4. Have undergone urogenital system surgery within the past three months; 5. Pregnancy or pregnancy plans during the study period; 6. Ultrasound examination indicates residual urine volume > 100mL or concurrent pulmonary disease; 7. Have a history of brain tumor surgery, spinal cord injury, or have been diagnosed with multiple sclerosis, Alzheimer's disease, stroke, Parkinson's disease and other neurological diseases; 8. Patients who could not tolerate the relevant treatment procedures in this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| quantitative alterations of key molecular proteins (ZO-1, E-cadherin,p-p65, TRPA1/NLRP3); | — |
Secondary
| Measure | Time frame |
|---|---|
| Changes in clinical symptoms (e.g., ?OABSS); | — |
Countries
China
Contacts
Public ContactZhao Yong
Shandong Provincial Hospital (Shandong Children's Hospital)
Outcome results
None listed