Postoperative cognitive dysfunction
Conditions
Interventions
Standard ETCO2 Group:During the operation, controlled ventilation was used to maintain PETCO2 at 35-44 mmHg
Normal high-limit ETCO2 group:During the operation, ETCO2 was maintained at 45-49mmHg through ventilation management
Sponsors
Yibin Third People's Hospital
Eligibility
Sex/Gender
Female
Age
65 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1.An elderly patient, aged 65 to 85 years, with ASA physical status I-II, is scheduled for gynecological laparoscopic surgery at a later date; 2. No severe cardiac, cerebral, hepatic or renal dysfunction, and no severe respiratory disease; 3. No significant abnormalities were found in the ophthalmological examination; 4. No cognitive dysfunction; 5. Agree to participate and sign the anesthesia informed consent form
Exclusion criteria
Exclusion criteria: 1. Previous history of neurosurgery or ophthalmic surgery; 2. Previous ocular (blindness, glaucoma, cataract, etc.) or neurological diseases (cerebral hemorrhage, brain trauma, cerebral hemorrhage) (including vascular malformation, cerebral infarction, etc.); 3. Allergic to the study drug; 4. Dysfunction of heart, lungs, liver, kidneys, endocrine system, etc; 5. Taking sedatives, antidepressants, and excessive alcohol consumption.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| End-tidal carbon dioxide;Optic nerve sheath diameter; | — |
Secondary
| Measure | Time frame |
|---|---|
| Neurological complications;MMSE Score; | — |
Countries
China
Contacts
Public ContactXiong Li
Yibin Third People's Hospital
Outcome results
None listed