Mood (Affective) Disorders
Conditions
Interventions
Conventional treatment group:Conventional treatment
Research Group 2:Conventional treatment +Mood Probiotics (Metabotropic)
Research Group 1:Conventional Treatment+Mood Probiotics (Mood Sleep)
Sponsors
The Third Affiliated Hospital Sun Yat-sen University
Eligibility
Sex/Gender
All
Age
10 Years to 18 Years
Inclusion criteria
Inclusion criteria: 1. Patients who meet the diagnostic criteria for mood disorders; 2. There is no gender restriction, with an age range of 10-18 years old; 3. In the acute phase of disease onset, HAMD score >= 17 points; 4. No previous use of chlorpromazine treatment; 5. Able to communicate effectively with researchers and research staff, fill out research related materials, understand informed consent forms, and obtain informed consent from subjects/family members/guardians/legal representatives.
Exclusion criteria
Exclusion criteria: 1.Within the two weeks prior to admission, there was an infection or autoimmune disease present; 2. Abnormal white blood cell count and significant liver and kidney function in blood routine; 3. Individuals with severe physical illnesses and neurological disorders; 4. History of peptic ulcer and gastrointestinal bleeding; 5. Pregnant and lactating patients; 6. There are contraindications for drug use.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Changes in gut microbiota composition and structure relative to baseline after 12 weeks of combined use of emotional probiotics;Changes in serum inflammatory factors relative to baseline after 12 weeks of intervention with emotional probiotics;After 12 weeks of combined use of emotional probiotics, the changes in patients' anxiety and depression scale scores relative to baseline; | — |
Secondary
| Measure | Time frame |
|---|---|
| After 12 weeks of combined use of emotional probiotics intervention, changes in patients' weight, BMI, waist circumference, hip circumference, waist-to-hip ratio, body fat and liver fat content, blood pressure, and basal metabolic rate relative to baseline; | — |
Countries
China
Contacts
Public ContactWu Xiaoli
The Third Affiliated Hospital Sun Yat-sen University
Outcome results
None listed