Wheezing and asthma in children
Conditions
Interventions
Observation group:N/A
Sponsors
The Zhangzhou Municipal Hospital of Fujian Province
Eligibility
Sex/Gender
All
Age
0.1 Years to 3 Years
Inclusion criteria
Inclusion criteria: 1. Aged between 6 months and 3 years, with no gender restriction. 2. First episode of wheezing requiring hospitalization. 3. Admission within 72 hours after the onset of wheezing. 4. Written informed consent provided by the legal guardian.
Exclusion criteria
Exclusion criteria: 1 A documented history of asthma or two or more prior episodes of wheezing. 2 Presence of underlying diseases such as congenital heart disease, bronchopulmonary dysplasia (BPD), immunodeficiency, or inherited metabolic disorders. 3 Use of systemic glucocorticoids or immunomodulators within two weeks prior to admission. 4 Inability to complete fractional exhaled nitric oxide (FeNO) testing or poor cooperation with pulmonary function testing. 5 Legal guardian refuses to participate in the study or is unable to comply with follow-up requirements
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Asthma diagnosis status;Number of wheezing recurrences;Hospitalization rate due to wheezing;Time to initiation and duration of inhaled corticosteroid (ICS) use; | — |
Secondary
| Measure | Time frame |
|---|---|
| FeNO dynamic trajectory subtypes;Baseline IFN-? level;Total IgE level;Peripheral blood eosinophil count;Results of 13 respiratory pathogen panel;Tidal breathing lung function parameters;IL-4,IL-13; | — |
Countries
China
Contacts
Public ContactZhang Jiaxiang
The Zhangzhou Municipal Hospital of Fujian Province
Outcome results
None listed