Postoperative pain
Conditions
Interventions
Control group (Group C):Intravenous infusion of normal saline (syringe 1 and syringe 2 both contain normal saline)
Dexamethasone group (Group D):Intravenous infusion of dexamethasone 8 mg (syringe 1) + normal saline (syringe 2)
Dexamethasone combined with dexmedetomidine group (Group DD):Intravenous infusion of dexamethasone 8 mg (syringe 1) + dexmedetomidine 1 µg/kg (syringe 2)
Sponsors
The People's Hospital of Tongnan District, Chongqing
Eligibility
Sex/Gender
All
Age
18 Years to 90 Years
Inclusion criteria
Inclusion criteria: 1. Age = 18 years; 2. Body mass index (BMI) < 30 kg/m²; 3. American Society of Anesthesiologists (ASA) physical status I–III; 4. Willing to participate in this study and sign the informed consent form;5. Electively perform upper limb fracture surgery under brachial plexus block.
Exclusion criteria
Exclusion criteria: 1. Patient refusal to participate; 2. Presence of neuropathy or sensory abnormality in the surgical limb; 3. Allergy or contraindication to any of the study drugs (ropivacaine, dexamethasone, dexmedetomidine); 4. Severe cardiac, pulmonary, hepatic, or renal disease; 5. Uncontrolled diabetes mellitus; 6. Coagulation dysfunction; 7. Systemic infection or local infection at the puncture site; 8. Pregnancy or breastfeeding; 9. History of alcohol/substance abuse; 10. History of chronic pain requiring regular opioid use within 1 month before surgery; 11. Inability to cooperate with follow-up or complete questionnaires.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The incidence of rebound pain ; | — |
Secondary
| Measure | Time frame |
|---|---|
| intensity of rebound pain;Onset time of rebound pain;NRS scores at rest and during movement within 48 hours postoperatively;Postoperative opioid consumption;Postoperative sleep assessment;Patient satisfaction;Incidence of chronic postoperative pain at 3 and 6 months;Adverse events (bradycardia, nausea and vomiting, etc.); | — |
Countries
China
Contacts
Public ContactXiaofeng Zhou
The People's Hospital of Tongnan District, Chongqing
Outcome results
None listed