Duchenne muscular dystrophy (DMD)
Conditions
Interventions
Index test:Global Longitudinal Strain (GLS), T1 Mapping, Extracellular Volume Fraction (ECV), Late Gadolinium Enhancement (LGE),Cardiac Magnetic Resonance (CMR)
Sponsors
Children's Hospital of Chongqing Medical University
Eligibility
Sex/Gender
All
Inclusion criteria
Inclusion criteria: 1.Children diagnosed with Duchenne muscular dystrophy (DMD) confirmed by genetic testing; 2.Ability to cooperate in completing echocardiography and cardiac magnetic resonance imaging (MRI) examinations; 3.Legal guardians provide written informed consent voluntarily, and the child, if capable, expresses assent;
Exclusion criteria
Exclusion criteria: 1.Clinical diagnosis of Becker muscular dystrophy (BMD) or other types of neuromuscular disorders; 2.Presence of other congenital or acquired heart diseases that may independently affect cardiac function assessment; 3.Contraindications to cardiac magnetic resonance (CMR) examination (e.g., non-MRI-compatible implants, allergy to gadolinium-based contrast agents, severe renal insufficiency, etc.); 4.The investigator determines that the family cannot cooperate to complete at least 3 years of regular follow-up;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cardiac Magnetic Resonance (CMR) data;Electrocardiogram (ECG) data; | — |
Secondary
| Measure | Time frame |
|---|---|
| Echocardiography data;Biochemical Testing result;two-dimensional speckle tracking echocardiography (2D-STE) data; | — |
Countries
China
Contacts
Public ContactSiqi Hong
Children's Hospital of Chongqing Medical University
Outcome results
None listed