Bisphosphonate-related osteonecrosis of the jaw
Conditions
Interventions
Case group:None
Control group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Meets the 2022 AAOMS BRONJ diagnostic criteria (exposed bone > 8 weeks, history of bisphosphonate use); 2. Has a long-term bisphosphonate history (intravenous ZA >= 5 times or oral >= 12 months); 3. Plans to undergo necrotic bone resection; 4. Age >= 18 years old
Exclusion criteria
Exclusion criteria: 1. History of head and neck radiotherapy; 2. Primary or metastatic tumors in the jaw; 3. Anti-angiogenic targeted therapy within 3 years; 4. Long-term use of glucocorticoids (>= 3 months and equivalent prednisone >= 7.5 mg/day or cumulative > 1 g); 5. Diabetes; 6. Continuous use of NSAIDs/COX-2 inhibitors for more than 7 days for the past 4 weeks.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Immunofluorescence expression scores of vascular molecules, inflammatory-NETs molecules, and osteogenic molecules; | — |
Secondary
| Measure | Time frame |
|---|---|
| The rate of empty lacunae in HE staining;Volume of necrotic bone; | — |
Countries
China
Contacts
Public ContactWang Kun
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed