tumor
Conditions
Interventions
Control group:Intraoperative anesthesia was maintained with a continuous infusion of normal saline, inhalation of sevoflurane, and infusion of remifentanil.
Experimental group:Intraoperative anesthesia was maintained with dexmedetomidine, inhalation of sevoflurane, and infusion of remifentanil.
Sponsors
Cancer Hospital Chinese Academy of Medical Sciences
Eligibility
Sex/Gender
All
Age
18 Years to 60 Years
Inclusion criteria
Inclusion criteria: 1.Patients aged 18 to 60 years; 2.ASA physical status I-II; 3.scheduled for minimally invasive abdominal surgery (e.g., pancreatic and gastric surgery, colorectal surgery, gynecological surgery, and laparoscopic urological surgery in the supine position).
Exclusion criteria
Exclusion criteria: 1.Patients who refuse to participate in this study; 2.BMI 30 kg/m²; 3.Sinus bradycardia (HR = 50 beats per minute); 4.Severe cardiac conduction block (e.g., second-degree or higher atrioventricular block); 5.Cardiac dysfunction (LVEF < 50%); 6.Systemic or major organ inflammation; 7.Severe anemia (HGB < 60 g/L); 8.Severe hepatic dysfunction (Child-Pugh score = 10); 9.Decompensated renal insufficiency or worse (e.g., serum creatinine = 133 µmol/L or glomerular filtration rate < 60 ml/min); 10.Thyroid dysfunction (either hypothyroidism or hyperthyroidism); 11.Neurological diseases; 12.Use of medications for central nervous system disorders; 13.Preoperative cognitive impairment (MMSE < 24); 14.Long-term use of a-receptor blockers; 15.Allergy to anesthetic agents.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The average end-tidal concentration of sevoflurane in the second hour of surgery.; | — |
Secondary
| Measure | Time frame |
|---|---|
| Wake-up time; | — |
Countries
China
Contacts
Public ContactNi Cheng
Cancer Hospital Chinese Academy of Medical Sciences
Outcome results
None listed