Acute Coronary Syndrome
Conditions
Interventions
Severe Periodontitis (High PISA):None
light Peridontitis (Low PISA):None
Sponsors
Inner Mongolia Forestry General Hospitai
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Age 18 to 75 years; 2.Confirmed diagnosis of acute coronary syndrome (including unstable angina, non-ST-segment elevation myocardial infarction, and ST-segment elevation myocardial infarction) according to current guidelines, with symptom onset within 24 hours; 3.Comorbid type 2 diabetes mellitus, diagnosed according to the American Diabetes Association or Chinese Diabetes Society criteria, or with a documented history of diabetes.
Exclusion criteria
Exclusion criteria: 1.Use of antibiotics, immunosuppressants, or systemic corticosteroids within the past 3 months; 2.History of active periodontal treatment (e.g., scaling and root planing, periodontal surgery) within the past 6 months; 3.Severe hepatic or renal dysfunction (alanine aminotransferase >3 times the upper limit of normal, or severe renal failure), malignancy, or autoimmune disease; 4.Presence of acute oral infection other than periodontitis; 5.Pregnant or breastfeeding women; 6.Psychiatric disorders, cognitive impairment, or any condition that in the investigator's judgment would make the patient unable to cooperate with the study or complete the 1-year follow-up.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Major Adverse Cardiovascular Events (MACE); | — |
Secondary
| Measure | Time frame |
|---|---|
| Periodontal Inflamed Surface Area (PISA);Serum High-sensitivity C-reactive Protein (hs-CRP);Serum 25-hydroxyvitamin D3;Serum Asprosin;Quality of Life Score (SF-36); | — |
Countries
China
Contacts
Public ContactWang Dongqing
Inner Mongolia Forestry General Hospitai
Outcome results
None listed