Chronic Obstructive Pulmonary Disease (COPD), Non-Small Cell Lung Cancer (NSCLC).
Conditions
Interventions
COPD combined NSCLC group:None
Sponsors
The Second Affiliated Hospital of the Army Medical University
Eligibility
Sex/Gender
All
Age
18 Years to 80 Years
Inclusion criteria
Inclusion criteria: 1. Cohort 1: Lung cancer group: (1) The patient age is ranging from 18 to 80 years old; (2) No obvious abnormalities were found in the pulmonary function test (FEV1/FVC >=0.7 after inhalation of bronchodilators); (3) Patients with initially treated locally advanced or metastatic NSCLC diagnosed by pathology. No surgical opportunity; (4) At least one measurable target lesion according to RECIST v1.1 criteria; (5) Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1; (6) Other malignant tumors are excluded. 2. Cohort 2: COPD combined NSCLC group: (1) The patient age is ranging from 18 to 80 years old; (2) The patient meets the diagnostic criteria for COPD as stipulated in the "Guidelines for Primary Diagnosis, Treatment and Management of Chronic Obstructive Pulmonary Disease in China"; (3) Patients with initially treated locally advanced or metastatic NSCLC diagnosed by pathology. No surgical opportunity; (4) At least one measurable target lesion according to RECIST v1.1 criteria; (5) Eastern Cooperative Oncology Group (ECOG) performance status score of 0-1; (6) Other malignant tumors are excluded.
Exclusion criteria
Exclusion criteria: 1. Use antibiotics or supplement probiotics in the recent period (within 3 months); 2. Patients with other lung diseases (such as asthma, bronchiectasis, pulmonary tuberculosis, interstitial lung disease); 3. Patients with severe gastrointestinal diseases; 4. Patients with autoimmune diseases; 5. Those who have previously received systemic anti-tumor treatments such as surgery, chemotherapy, radiotherapy or targeted therapy; 6. Patients with EGFR mutations, ALK fusions, ROS1 fusions, RET fusions, KRAS G12C/D mutation, C797X mutation, NTRK fusion, and BRAF mutation.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| microbiota characteristics; | — |
Secondary
| Measure | Time frame |
|---|---|
| progression free survival;objective response rate;overall survival; | — |
Countries
China
Contacts
Public ContactBai Li
The Second Affiliated Hospital of the Army Medical University
Outcome results
None listed