Stroke-associated pneumonia
Conditions
Interventions
Combined group (acetylcysteine nebulized inhalation combined with piperacillin tazobactam):None
Sponsors
Yuebei People's Hospital Affiliated to Shantou University Medical College
Eligibility
Sex/Gender
All
Age
18 Years to No maximum
Inclusion criteria
Inclusion criteria: 1. Conform to the diagnostic criteria of SAP; 2. Stroke patients who are not receiving mechanical ventilation, aged =18 years, and did not have pulmonary infection before stroke; 3. No history of using immunosuppressants, glucocorticoids, or other immunotherapy within 6 months prior to enrollment; 4. Anti-infective treatment using piperacillin/tazobactam.
Exclusion criteria
Exclusion criteria: 1. Combined with infections in other parts; 2. Previous history of resistance to piperacillin/tazobactam, or allergy to the drugs used in this study; 3. Comorbidities such as congenital structural abnormalities of the respiratory system, chest trauma, chronic obstructive pulmonary disease, spontaneous pneumothorax, bronchial asthma, or other respiratory diseases, or comorbid chronic respiratory failure; 4. Combined pregnancy, severe endocrine and metabolic disorders, hematological diseases, or cardiac, hepatic, and renal dysfunction.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Levels of CD3+, CD4+, and CD8+ T lymphocytes;The levels of inflammatory marker (PCT, CRP, IL-6); | — |
Secondary
| Measure | Time frame |
|---|---|
| Duration of hospitalization;Adverse reaction; | — |
Countries
China
Contacts
Public ContactYu Hongying
Yuebei People's Hospital Affiliated to Shantou University Medical College
Outcome results
None listed