bladder cancer
Conditions
Interventions
Normal saline group:Preoperative intravesical instillation of normal saline
Lidocaine group:Preoperative intravesical instillation of lidocaine
Sponsors
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Eligibility
Sex/Gender
All
Age
18 Years to 85 Years
Inclusion criteria
Inclusion criteria: 1. Aged 18-85 years; 2. ASA class I-III; 3. Patients with primary Ta-T1 stage bladder cancer scheduled for elective TURBT under general anesthesia; 4. According to the European Organisation for Research and Treatment of Cancer (EORTC) recurrence risk score, the patient has a preoperative cystoscopy-determined score greater than 1; 5. Informed consent obtained from the patient or their legal representative.
Exclusion criteria
Exclusion criteria: 1. Emergency surgery; 2. Palliative surgery; 3. Confirmed or suspected allergy to the investigational drug; 4. Presence of metastases to other organ systems; 5. Receipt of preoperative adjuvant chemotherapy, targeted therapy, or immunotherapy; 6. Pregnant or breastfeeding women; 7. Patients deemed unsuitable for participation by the investigator, e.g., those at high risk of loss to follow-up due to geographic location, communication issues, or other reasons; 8. Currently participating in other clinical trials.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Postoperative recurrence?free survival; | — |
Secondary
| Measure | Time frame |
|---|---|
| Postoperative analgesic consumption within the first 24 hours.;Visual Analog Scale (VAS) scores for catheter-related discomfort, resting pain, and nausea and vomiting at 1 hour and 24 hours postoperatively;The percentage decrease in urine DNA methylation levels at 3, 6, and 12 months postoperatively compared with the preoperative level; | — |
Countries
China
Contacts
Public ContactTian Jie, Xuan Wei
Renji Hospital, Shanghai Jiao Tong University School of Medicine
Outcome results
None listed