perioperative pain
Conditions
Interventions
Intervention Group (Stimulation Group):Patients in the stimulation group were administered intraoperative taVNS throughout the procedure
Control Group (Sham Stimulation Group):Intraoperative taVNS sham stimulation
Sponsors
Fifth Affiliated Hospital, Sun Yat-Sen University
Eligibility
Sex/Gender
All
Age
18 Years to 75 Years
Inclusion criteria
Inclusion criteria: 1.Voluntarily sign the informed consent form. 2.Aged 18 to 75 years. 3.ASA physical status Grade I–III. 4.Scheduled for endoscopic nasopharyngectomy under general anesthesia. 5.No communication barriers, and educational level sufficient to complete preoperative assessments.
Exclusion criteria
Exclusion criteria: 1.Contraindications to taVNS: implantation of a cardiac pacemaker or concurrent use of other electrical stimulation therapies; inability to cooperate with treatment (e.g., dementia, Parkinson’s disease, epilepsy, etc.); excessive skin lesion area; infection or skin injury at the stimulation and puncture sites. 2.Patients with severe primary or secondary diseases that may significantly increase surgical risk, delay or interrupt surgery. These include but are not limited to: Child–Pugh class C liver failure; end-stage renal disease with persistent or uncorrectable electrolyte disturbances; severe hematological diseases (e.g., severe coagulation disorders); severe respiratory failure requiring respiratory support; severe cardiac insufficiency or active/progressive infectious diseases. 3.Administration of drugs known to affect autonomic nervous function within the past 1 week, including sedatives or antidepressants. 4.Current participation or participation in other clinical trials within the previous 12 weeks. 5.Patients undergoing intraoperative tracheotomy. 6.Preoperative chronic pain lasting more than 3 months or requiring long-term medication. 7.Patients requiring intraoperative temporal muscle flap repair.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Intraoperative opioid consumption;Time-Weighted Average Pain Score over 48 Postoperative Hours; | — |
Secondary
| Measure | Time frame |
|---|---|
| Rescue analgesia rate;NRS pain scores;Activities of Daily Living (ADL) scale score;Incidence of moderate-to-severe pain (NRS = 4) within 48 hours postoperatively;Postoperative length of hospital stay;Cumulative opioid consumption within 48 hours postoperatively;Quality of Recovery-15 (QoR-15) score;Time to extubation;Rate of premature PCA pump discontinuation;Incidence of pricking sensation at the stimulation site;Incidence of dizziness;Rescue analgesic dosage; | — |
Countries
China
Contacts
Public ContactDezhao Liu
Fifth Affiliated Hospital, Sun Yat-Sen University
Outcome results
None listed