necrotizing enterocolitis
Conditions
Interventions
Intervention group (exclusive breastfeeding group):Infants should be fed fresh breast milk at least twice daily
all other feeding protocols will strictly follow the same feeding regimen and breast milk fortifier administration schedule as the control group. Fresh breast milk is defined as milk that has not been
Control group (non-exclusive breastfeeding group):Breastfeeding in this group is defined as the use of breast milk that has been refrigerated, frozen, pasteurized, or expressed more than 4 hours prior
Sponsors
Nanjing Women and Children's Healthcare Hospital
Eligibility
Sex/Gender
All
Age
No minimum to 2 Years
Inclusion criteria
Inclusion criteria: 1. Gestational age less than 32 weeks 2. Admission to the neonatal intensive care unit after birth 3. Mothers in the intervention group are willing to provide fresh breast milk at least twice daily 4. The participant’s guardian consents and is able to comply with the follow-up study protocol
Exclusion criteria
Exclusion criteria: 1. Contraindications for mothers: Breastfeeding should be discontinued in cases of HIV infection or severe medical conditions, such as chronic nephritis, diabetes, malignant tumors, psychiatric disorders, epilepsy, or heart failure; chemotherapy or radiopharmaceutical therapy 2. Contraindications for infants: Such as congenital gastrointestinal malformations; severe asphyxia requiring long-term use of muscle relaxants or high-dose vasopressors; severe allergies; or during the acute phase of an illness; 3. The study participant’s guardian must provide consent and be able to comply with the follow-up study protocol.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Cumulative incidence of NEC (Bell Grade II or higher); | — |
Secondary
| Measure | Time frame |
|---|---|
| Incidence of late-onset sepsis;Time to achieve total enteral feeding;Length of hospital stay;Mortality rate;Incidence of BPD, ROP, and EOC;Physical Growth and Neurodevelopment; | — |
Countries
China
Contacts
Public ContactShuping Han
Nanjing Women and Children's Healthcare Hospital
Outcome results
None listed